ESTIMATE OF THE EFFICIENCY OF THE SYNTHET IC ANTIOXIDANT DIBUNOL IN CHEMOTHERAPY OF EXPERIMENTAL-TUMORS

We studied the therapeutic efficiency of the synthetic antioxidant Dib unol alone and in combination with cytostatic drugs on animals with ex perimental tumors after simultaneous and successive administration. In troduction of Dibunol to animals (tumor carriers) soon after the trans plantation of tumor cells had adverse consequences, stimulated tumor g rowth and reduced the life span of animals. Dibunol exerted a therapeu tic effect only in cases of developed tumors. Simultaneous introductio n of cytostatic drugs (cyclophosphamide, dimethylnitrosourea, ADEKO) a nd Dibunol to tumor carriers was efficient and increased the mean life span of animals. The antitumor effect of the cyclophosphamide-Dibunol combination did not, in practice, depend on the interval between intr oductions of these drugs. However, the mean life span and survival of animals were somewhat higher the intervals between introductions or si multaneous application of the drugs were short.