PATHOLOGY OF CEREBRAL METASTASES

Important pathologic features of cerebral metastases include the route of spread of tumor cells to the brain, differences among metastases b ased on location in dura mater, leptomeninges, and brain parenchyma, d ifferences based on primary tumor site, both known and unknown, the me ans of spread of metastases within the brain, and the brain's reaction s to metastases. Immunohistochemistry and electron microscopy are incr easingly used in the pathologic evaluation of cerebral metastasis.