ORAL FLUCONAZOLE IN THE TREATMENT OF PULMONARY CRYPTOCOCCOSIS IN NON-AIDS PATIENTS

Four non-AiDS patients with pulmonary cryptococcus infection who could not tolerate amphotericin B treatment were given oral fluconazole at a dose oi 600mg once daily for 4-5 weeks followed by 400mg once daily for 10-12 weeks resulting in cure. Aii patients did not have relapse o i disease when followed-up for 8-24 months alter cessation oi treatmen t. The very good tolerance of oral fluconazole by these patients sugge sts that such effective monotherapy should be evaluated further in non -AiDS patients with pulmonary cryptococcosis.