EFFECTS OF RELEASED PRODUCTS FROM PLATELETS ON NEUTROPHILIC ADHESION TO ENDOTHELIAL-CELLS AND NYLON FIBERS

In this study, the effects of platelet release products (PRPr), ATP, a nd ADP on the adhesion of human neutrophils to human umbilical vein en dothelial cells (HUVEC) and nylon fibers (NF) are described and the im plications of various adhesion molecules are considered, Adhesion of n eutrophils to HUVEC and NF was increased by PRPr, ATP, and ADP, while their adhesion-increasing actions were cancelled or considerably repre ssed by apyrase treatment, When anti-CD11a or anti-CD11b was added to neutrophils with PRPr, ATP, or ADP, the adhesion-increasing action was cancelled or considerably repressed, On the other hand, anti-ICAM-1 a nd anti-CD35 had no significant effects on this action, The above resu lts indicated that platelets, through ATP and ADP in PRPr, increased t he adhesion of neutrophils to endothelial cells and foreign bodies, Al though it was suggested that the adhesion-increasing action was at lea st partially based on CD11a and CD11b, ICAM-1 and CD35 had no part in the enhancement of the adhesion.