POSTPRANDIAL LIPEMIA IN OBESE MEN WITH ABDOMINAL FAT PATTERNING

Objective. The purpose of this study was to assess differences in meas ures of postprandial triglyceride (TG) clearance between obese men wit h abdominal fat patterning (OAF) and men of desirable weight (DW). It was hypothesized that the OAF men would have impaired postprandial TG clearance. Experimental design. A comparative design was used. Setting . Data were collected in a research laboratory with access to blood an alysis instrumentation. Participants. Fourteen healthy, physically act ive, normolipemic men (7 OAF and 7 DW) were studied. Interventions. Ea ch subject consumed an oral fat load (78 grams of fat) and blood sampl es were collected every hour for 8 hours. Measures. Measures of postpr andial lipemia included: incremental TG area, total TG area, time to p eak TG concentration, maximal change in TG concentration, and time to return to baseline TG concentration. Results. OAF men had significantl y greater total area under the TG curve (24.7+/-1.09 vs 16.1+/-1.3 mmo l-L(-1). 8 hours, p=0.003) and greater maximum TG change (2.0+/-0.3 vs 1.2+/-0.2 mmol-L(-1), p=0.03) following the oral fat load. Additional ly, the total area under the TG curve was positively correlated with b aseline TG concentrations (r=0.53) and inversely correlated with basel ine HDL(2) concentrations (r=0.64). Baseline HDL(2) concentrations wer e inversely correlated with time to return to TG baseline (r=0.57). Co nclusions. Normal fasting lipoprotein profiles and regular physical ac tivity do not preclude OAF men from having pronounced postprandial lip emia.