TACHYKININ AND KININ RECEPTOR ANTAGONISTS - THERAPEUTIC PERSPECTIVES IN ALLERGIC AIRWAY DISEASE

The morbidity of allergic airway disease and the number of deaths resu lting from it have not declined in the past ten years. The multiplicit y of mediators released in the acute allergic reaction and our limited knowledge of the basic mechanisms that drive chronic inflammation hav e hampered the design of effective therapeutic regimens for this type of disease. In this article, Claude Bertrand and Pierangelo Geppetti s ummarize recent studies in which new, potent and selective tachykinin and kinin receptor antagonists demonstrate the involvement of tachykin ins and kinins in airway anaphylaxis, and review how these antagonists might be of use in treating allergic asthma and rhinitis.