Ruminant animals acquire their amino acids from the small intestinal d
igestion of ruminally derived microbial protein and dietary protein wh
ich has escaped ruminal degradation. The UK metabolizable protein syst
em provides a framework with which the net absorption of amino acids f
rom the small intestine is computed in relation to the animal's requir
ements and is based largely upon a set of criteria by which feedstuffs
are evaluated. While conceptually the system has many positive featur
es, a number of serious weaknesses have been identified, particularly
with respect to the techniques used to evaluate feedstuffs. Some of th
ese issues are considered, particularly the over-reliance which is pla
ced upon in vitro methodologies which have not been adequately validat
ed against in vivo observations and have been shown to give unacceptab
le variation. Attention is also drawn to the inadequate representation
of host tissue metabolism within such systems, for example, the impor
tance of splanchnic metabolism with respect to overall nutrient utiliz
ation. It is concluded that improved representation of energy (i.e. ca
rbohydrate) and protein interactions within the whole animal and not s
imply within the gastro-intestinal tract is urgently required; this in
evitably will lead to a change in research direction. Equally, support
for a mechanistic understanding rather than an empirical representati
on of protein metabolism in ruminant livestock is presented, given tha
t the demands upon the ruminant industry, particularly with respect to
predictability of animal response, is likely to increase as a consequ
ence of increased consumer impact on the marketing of animal products.