EFFECT OF USP APPARATUS-1 AND APPARATUS-2 AT DIFFERENT ROTATIONAL SPEEDS ON DISSOLUTION OF NIACIN FORMULATIONS

Authors
KIRCHHOEFER RD HAMILTON JF
Citation
Rd. Kirchhoefer et Jf. Hamilton, EFFECT OF USP APPARATUS-1 AND APPARATUS-2 AT DIFFERENT ROTATIONAL SPEEDS ON DISSOLUTION OF NIACIN FORMULATIONS, Journal of AOAC International, 79(4), 1996, pp. 1005-1008
Citations number
2
Categorie Soggetti
Chemistry Analytical
Journal title
Journal of AOAC International → ACNP
ISSN journal
10603271
Volume
79
Issue
4
Year of publication
1996
Pages
1005 - 1008
Database
ISI
SICI code
1060-3271(1996)79:4<1005:EOUAAA>2.0.ZU;2-Y
Abstract
Forty-four niacin formulations were examined by the United States Phar macopeia dissolution test, consisting of 0.1N HCl with apparatus 1 and 2. Each formulation was tested with apparatus 1 (basket) at 100 rpm a nd apparatus 2 (paddle) at 50 and 100 rpm. Dissolution results varied widely among manufacturers.