Rd. Kirchhoefer et Jf. Hamilton, EFFECT OF USP APPARATUS-1 AND APPARATUS-2 AT DIFFERENT ROTATIONAL SPEEDS ON DISSOLUTION OF NIACIN FORMULATIONS, Journal of AOAC International, 79(4), 1996, pp. 1005-1008
Forty-four niacin formulations were examined by the United States Phar
macopeia dissolution test, consisting of 0.1N HCl with apparatus 1 and
2. Each formulation was tested with apparatus 1 (basket) at 100 rpm a
nd apparatus 2 (paddle) at 50 and 100 rpm. Dissolution results varied
widely among manufacturers.