A COMMENTARY ON THE TOPOLOGICAL CHIRALITY AND ACHIRALITY OF MOLECULES

The concept of topological chirality is traced from its historic origi ns to its present-day connection to chemistry. In contrast to geometri cal chirality, the topological chirality of molecules depends on model s of bonding and is not directly tied to experimentally observable chi rality phenomena. Nevertheless, studies dealing with the topological c hirality and achirality of molecular graphs have played a significant role in an area where chemistry and topology intersect.