MICROBIAL HYDROXYLATION OF YDROXY-18,19-DINOR-17-ALPHA-PREGN-4-EN-20-YN-3-ONE

Authors
HU SH TIAN XF SUN YH HAN GD
Citation
Sh. Hu et al., MICROBIAL HYDROXYLATION OF YDROXY-18,19-DINOR-17-ALPHA-PREGN-4-EN-20-YN-3-ONE, Steroids, 61(7), 1996, pp. 407-410
Citations number
11
Categorie Soggetti
Biology,"Endocrynology & Metabolism
Journal title
Steroids → ACNP
ISSN journal
0039128X
Volume
61
Issue
7
Year of publication
1996
Pages
407 - 410
Database
ISI
SICI code
0039-128X(1996)61:7<407:MHOY>2.0.ZU;2-F
Abstract
The microbial transformation of the racemic mixture of 13-ethyl-17 bet a-hydroxy-18,19-dinor-17 alpha-pregn-4-en-20-yn-3-one (1) was investig ated. Rhizopus nigricans (AS 3.2050), R. arrhizus (AS 3.4523), Aspergi llus niger (AS 3.2744), A. ochraceus (AS 3.1408), and Curvularia lunat a (NRRL 4381) transformed 1 into its 10 beta-hdroxy derivative (2) as a major metabolite. Biotransformation of 1 by Aspergillus ochraceus AS 3.1408 afforded 7 beta-hydroxy derivative (3) as the only product.