REGIOSELECTIVE OXIDATION OF CHOLESTEROL AND RELATED STEROIDS WITH IODOSYLBENZENE CATALYZED BY PHA-[O-(4N-METHYL-ISONICOTINAMIDOPHENYL)]PORPHYRIN IN PHOSPHOLIPID-VESICLES

Authors
CHAUHAN SMS SHARMA TK
Citation
Sms. Chauhan et Tk. Sharma, REGIOSELECTIVE OXIDATION OF CHOLESTEROL AND RELATED STEROIDS WITH IODOSYLBENZENE CATALYZED BY PHA-[O-(4N-METHYL-ISONICOTINAMIDOPHENYL)]PORPHYRIN IN PHOSPHOLIPID-VESICLES, Indian journal of chemistry. Sect. B: organic chemistry, including medical chemistry, 35(8), 1996, pp. 779-784
Citations number
19
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Indian journal of chemistry. Sect. B: organic chemistry, including medical chemistry → ACNP
ISSN journal
03764699
Volume
35
Issue
8
Year of publication
1996
Pages
779 - 784
Database
ISI
SICI code
0376-4699(1996)35:8<779:ROOCAR>2.0.ZU;2-K
Abstract
The oxidation of cholesterol and stigmasterol with iodosylbenzene cata lyzed by 5,10,15,20 - alpha,alpha,alpha,alpha- [O - (4N-methylisonicot inamido) phenyl]porphyrinatomanganese(III) acetate gives 5 alpha, 6 al pha-epoxides and 5 beta, 6 beta-epoxides in homogeneous medium and pho spholipid vesicles in different yields. The higher yield of 5 beta, 6 beta-epoxide of above steroids in phospholipid vesicles than homgeneou s medium indicate that oxidation is more regioselective in phospholipi d vesicles than the homogeneous medium. The incorporation of manganese (III) porphyrin and its metal free porphyrin in phospholipid vesicles have been studied by the UV-visible, Fluorescence, Quasi Laser Light S cattering and Transmission Electron Microscopic techniques.