IN-VITRO ACTIVITY OF PENICILLIN-G PLUS SULBACTAM IN COMPARISON WITH OTHER BETA-LACTAMASE INHIBITOR COMBINATIONS AND OXACILLIN AGAINST STAPHYLOCOCCI

Authors
JANSEN B PERDREAUREMINGTON F PULVERER G
Citation
B. Jansen et al., IN-VITRO ACTIVITY OF PENICILLIN-G PLUS SULBACTAM IN COMPARISON WITH OTHER BETA-LACTAMASE INHIBITOR COMBINATIONS AND OXACILLIN AGAINST STAPHYLOCOCCI, Zentralblatt fur Bakteriologie, 284(2-3), 1996, pp. 297-301
Citations number
6
Categorie Soggetti
Microbiology,Virology
Journal title
Zentralblatt fur Bakteriologie → ACNP
ISSN journal
09348840
Volume
284
Issue
2-3
Year of publication
1996
Pages
297 - 301
Database
ISI
SICI code
0934-8840(1996)284:2-3<297:IAOPPS>2.0.ZU;2-A
Abstract
The in-vitro activity of penicillin G in combination with the beta-lac tamase inhibitor, sulbactam, against penicillin-sensitive S. aureus (n = 10) and penicillin-resistant, methicillin-sensitive S. aureus (n = 69) and S. epidermidis (n = 20) was tested in comparison with ampicill in/sulbactam, amoxicillin/clavulanic acid, piperacillin/tazobactam and oxacillin. The combination of penicillin G plus sulbactam was found t o lead to MIC values for beta-lactamase producing staphylococci compar able to those for penicillin-sensitive staphylococci,with MIC(90) valu es between less than or equal to 0,03 mg/L and 0.06 mg/L.