RECENT ADVANCES IN THE FIELD OF MATRIX METALLOPROTEINASE INHIBITORS

Matrix metalloproteinases (MMPs) are involved in the normal processes of tissue remodelling and repair, but have increasingly been implicate d in a range of disease states where they are over-expressed. This rev iew summarises developments in the design and clinical evaluation of s ynthetic MMP inhibitors since the subject was last covered in this jou rnal in 1995.