ALLELIC VARIANTS OF HUMAN CALCITONIN RECEPTOR IN THE JAPANESE POPULATION

Authors
NAKAMURA M ZHANG ZQ SHAN L HISA T SASAKI M TSUKINO R YOKOI T KANAME A KAKUDO K
Citation
M. Nakamura et al., ALLELIC VARIANTS OF HUMAN CALCITONIN RECEPTOR IN THE JAPANESE POPULATION, Human genetics, 99(1), 1997, pp. 38-41
Citations number
20
Categorie Soggetti
Genetics & Heredity
Journal title
Human genetics → ACNP
ISSN journal
03406717
Volume
99
Issue
1
Year of publication
1997
Pages
38 - 41
Database
ISI
SICI code
0340-6717(1997)99:1<38:AVOHCR>2.0.ZU;2-X
Abstract
Evidence from cDNA cloning has shown that calcitonin receptors (CTRs) have seven potential transmembrane domains. In this study, structural analysis of CTRs from ten cultured human tumor cell lines and 117 huma n blood samples demonstrated allelic variants at the 1377th nucleotide in intracellular domain 4, expressing either proline or leucine as th e 463rd amino acid. It was found that the variant with proline at this site was the more prevalent type of CTR among the Japanese population .