Jp. Konopelski et al., SYNTHETIC STUDIES ON DIAZONAMIDE .A. BENZOFURANONE-TYROSINE AND INDOLE-OXAZOLE FRAGMENT SUPPORT STUDIES, Synlett, (7), 1996, pp. 609
This paper discloses efforts toward the total synthesis of the marine
natural product cytotoxin diazonamide A. Specifically addressed are ef
ficient procedures for the synthesis of suitably substituted benzofura
none and indole systems (C10-C17 and C18-C25 of the final product, res
pectively). In addition, methods for incorporation of the tyrosine res
idue, acylation of C10, elaboration of the C16-C18 biaryl bond, and fo
rmation of the oxazole ring comprising C26-C28 have been explored.