MILD AND EFFICIENT PREPARATION OF ALKYNEPENTACARBONYLDICOBALT COMPLEXES CONTAINING THE CHIRAL (R)-(-GLYPHOS LIGAND())

A range of diastereomeric alkynepentacarbonyldicobalt complexes contai ning the (R)-(+)-Glyphos ligand have been prepared in moderate to good yields under standard thermal conditions. Additionally, novel tertiar y amine N-oxide mediated reactions have been developed which allow the synthesis of the same range of complexes at room temperature with goo d selectivity in consistently high yields. Optically pure (R)-(+)-Glyp hos containing complexes have been obtained by preparative HPLC separa tion of the sets of diastereomeric compounds. Finally, the amine N-oxi de techniques allow the rapid and clean preparation of alkynepentacarb onyltriphenylphosphinedicobalt complexes in good to high yields at roo m temperature.