PAPYRACILLIC ACID, A NEW PENICILLIC ACID ANALOG FROM THE ASCOMYCETE LACHNUM-PAPYRACEUM

The ascomycete Lachnum papyraceum is an efficient producer of bioactiv e and chlorinated metabolites, in which chlorine to some extent can be exchanged for bromine in fermentations to which bromide has been adde d. However, large amounts of bromide (100 mM CaBr2) alter the secondar y metabolism of the fungus, and it produces papyracillic acid as the m ain metabolite. Papyracillic acid is a new bioactive 1,6-dioxaspiro[4, 4]nonene derivative in equilibrium with the open-chain form, and relat ed to the mycotoxin penicillic acid. Copyright (C) 1996 Published by E lsevier Science Ltd