The pathogenesis of amyloidosis is not well understood. Here, Zafer Al
i-Khan, Weihua Li and Sic L. Chan present a metazoan parasite mouse mo
del of reactive amyloidosis, review the relationship between chronic i
nflammation and multiorgan AA amyloidosis and postulate how ubiquitin
might function in the processing of serum amyloid A and AA amyloid for
mation in the endosomes-lysosomes of activated murine reticuloendothet
ial cells.