LIPID-PEROXIDATION - THE ROLE OR CA2+ AND PROTECTION BY CALCININE

When calcinine (A-23187) (2 mu M), a known Ca2+ ionophore, is present, a significant protection is observed to a mitochondrial suspension un dergoing lipid peroxidation by Fe2+-citrate complex. A-23187 can remov e Ca2+, which seems to have an important role in the lipid peroxidatio n process, from its 'lesive sites' and consequently preventing the dam age. This information has importance in terms of knowing the mechanism s and avoiding the damages of lipid peroxidation that occur in some pa thological cases such as tumor promotion and hemochromatosis.