IN-VIVO IN-VITRO CORRELATIONS OF NITROFURANTOIN MATRIX TABLET FORMULATIONS

In our recent study, a new sustained release dosage form of nitrofuran toin (nft) as matrix tablets by 2(2) factorial design has been prepare d by using different drug:polymer ratios. The effect of the polyvinylp yrolidone contents of nft matrix tablets on dissolution rate and bioav ailability of the drug have been evaluated. The ideal formulation whic h fitted at USP XXII dissolution norms was tested by in vivo experimen ts. The satisfactory correlation was also obtained between the in vivo and the in vitro results. This study suggested that the amounts of nf t excreted in urine can be calculated by using in vitro dissolution re sults and sampling time.