UVEITIS DURING TREATMENT OF DISSEMINATED MYCOBACTERIUM-AVIUM-INTRACELLULARE COMPLEX INFECTION WITH THE COMBINATION OF RIFABUTIN, CLARITHROMYCIN AND ETHAMBUTOL

Authors
LOWE SH KROON FP BOLLEMEYER JG STRICKER BHC VANTWOUT JW
Citation
Sh. Lowe et al., UVEITIS DURING TREATMENT OF DISSEMINATED MYCOBACTERIUM-AVIUM-INTRACELLULARE COMPLEX INFECTION WITH THE COMBINATION OF RIFABUTIN, CLARITHROMYCIN AND ETHAMBUTOL, Netherlands journal of medicine, 48(6), 1996, pp. 211-215
Citations number
34
Categorie Soggetti
Medicine, General & Internal
Journal title
Netherlands journal of medicine → ACNP
ISSN journal
03002977
Volume
48
Issue
6
Year of publication
1996
Pages
211 - 215
Database
ISI
SICI code
0300-2977(1996)48:6<211:UDTODM>2.0.ZU;2-A
Abstract
Three patients with a cellular immunodeficiency were treated with rifa butin, clarithromycin and ethambutol for a disseminated infection with Mycobacterium avium-intracellulare complex (MAC). The patients develo ped uveitis, some-times in combination with a transient rash, arthralg ia, arthritis, jaundice and pseudojaundice. It seems likely that these reactions were caused by rifabutin, alone or together with other drug s such as clarithromycin. These adverse reactions probably depend on t he dose, metabolism and excretion of the drug. Inhibition of cytochrom e P450 seems to be an important mechanism.