W. Dickey et Jb. Mcconnell, HOW MANY HOSPITAL VISITS DOES IT TAKE BEFORE CELIAC SPRUE IS DIAGNOSED, Journal of clinical gastroenterology, 23(1), 1996, pp. 21-23
We studied the hospital records of patients with celiac sprue in order
to determine how frequently hospital specialists failed to make the d
iagnosis. Over a 7 1/2-year period, 39 patients were diagnosed, 49% wi
thin the last is months of the study period. Fourteen patients (39%) h
ad been referred to the hospital a total of 30 times with features sug
gestive of celiac sprue, yet without being successfully diagnosed: the
delay between initial referral and diagnosis was >6 years in nine of
these patients. The diagnosis was made by gastroenterologists or other
internists in 38 (97%) patients. Gastroenterologists had an 85% (33 o
f 39) diagnostic success rate, other internists 63% (five of eight), a
nd surgeons 7% (one of 14). None of eight referrals to other specialis
ts led to diagnosis. While a history of diarrhea was more likely to le
ad to diagnosis, it was reported by only 59% (23 of 39) of patients at
the time of diagnosis and at only 46% (32 of 69) of referrals; furthe
rmore, it did not prompt correct diagnosis in 28% (nine of 32). Anemia
was the sole manifestation of celiac sprue at 17 referrals, and corre
ct diagnosis was made in only seven (41%), all by gastroenterologists.
The perceived rarity of celiac sprue reflects its underdiagnosis. Dia
gnosis is still delayed even in patients with classic diarrhea, and th
ere is still a failure to appreciate the possible manifestations of sp
rue, including anemia without gastrointestinal symptoms. Because patie
nts may be referred to specialists other than gastroenterologists with
symptoms arising from celiac sprue, a wider knowledge of its manifest
ations is called for.