Jw. Jukema et al., THE INFLUENCE OF ANGIOGRAPHIC END-POINTS ON THE OUTCOME OF LIPID INTERVENTION STUDIES - A PROPOSAL FOR STANDARDIZATION, Angiology, 47(7), 1996, pp. 633-642
The aims of this study were to evaluate the influence of different cor
onary angiographic endpoints on the outcome of lipid intervention stud
ies and to formulate a proposal for angiographic endpoint standardizat
ion. In recent angiographic intervention studies a confusing diversity
in angiographic endpoints has been used to determine the outcome. In
addition, differences in study populations (eg, bypass patients includ
ed or not) could influence results. This makes comparisons between stu
dies cumbersome and raises the question to what extent the results of
various studies may be subject to the selection of angiographic endpoi
nts. The investigators compared three frequently used endpoints (mean
segment diameter, minimum obstruction diameter, and % stenosis) in a g
roup of 505 patients who had just finished a trial designed to assess
the effect of cholesterol lowering by pravastatin. To exclude a potent
ial bias this analysis was carried out at the time that the study was
still blinded. They found poor intercorrelation coefficients for mean
segment diameter calculated in different ways, ranging from 0.55 to 0.
95, dependent on inclusion or exclusion of segments influenced by coro
nary angioplasty or bypass grafting and on whether or not a value of 0
was assumed for occluded segments and segments distal to occlusions.
The correlation between mean segment diameter and minimum obstruction
diameter was 0.79; between minimum obstruction diameter and % stenosis
, 0.85; and between mean segment diameter and % stenosis, only 0.64. D
ifferent endpoints sometimes correlate poorly. This may lead to differ
ences in results of angiographic intervention trials. The authors prop
ose standardization by (1) using both mean segment diameter and minimu
m obstruction diameter as endpoints and (2) excluding from the primary
analysis segments influenced by mechanical interventions.