It is shown that in realistic SUSY GUT models of quark and lepton mass
es both the proton decay rate and branching ratios differ in general f
rom those predicted in the minimal SU(5) supersymmetric model. The obs
ervation of proton decay, and in particular the branching ratio B[(p -
-> pi(+)<(nu)over bar>)/(p --> K+<(nu)over bar>)], would thus allow de
cisive tests of these fermion mass schemes. It is shown that the charg
ed lepton decay mode p --> K-0 mu(+) arising through gluino dressing d
iagrams is significant and comparable to the neutrino modes in large t
an beta models. Moreover, it is found that in certain classes of model
s the higgsino-mediated proton decay amplitudes are proportional to a
model-dependent group-theoretical factor which in some cases can be qu
ite small. There is thus a natural suppression mechanism which can exp
lain without adjustment of parameters why in the context of SUSY GUTs
proton decay has not yet been seen. The most interesting such class co
nsists of SO(10) models in which the dominant flavor-symmetric contrib
ution to the up-quark mass matrix comes from an effective operator of
the form 16(i)16(j)10(H)45(H), where [45(H)] points approximately in t
he I-3R direction. This class includes a recent model of quark and lep
ton masses proposed by the authors.