FLUVOXAMINE TREATMENT IN CLOZAPINE-INDUCED OBSESSIVE-COMPULSIVE SYMPTOMS IN SCHIZOPHRENIC-PATIENTS

Interest in the association of obsessive-compulsive (OC) symptoms and schizophrenia has been reawakened since the introduction of clozapine for treatment of schizophrenia. We describe the appearance of this dis order and examine the efficacy of adding fluvoxamine to ongoing clozap ine treatment of the OC and schizophrenic symptoms. Four patients with DSM-III-R schizophrenic disorder, in whom OC symptoms appeared during the course of clozapine treatment, are reported. In two patients, flu voxamine, a serotonin-selective reuptake inhibitor (SSRI), was added t o clozapine under open-trial conditions. The patients were serially as sessed by using the Brief Psychiatric Rating Scale, Yale-Brown Obsessi ve-Compulsive Scale, and Scale for the Assessment of Negative Symptoms . The de novo occurrence and eventual spontaneous reduction of OC symp toms were noted in two schizophrenic patients treated with clozapine. In the other two patients, one with previous and the other with a fami ly history of OC disorder, the addition of fluvoxamine to clozapine wa s effective in eliminating the OC symptoms. A concomitant improvement in the schizophrenic symptomatology was seen as well. It appears that disabling OC symptoms may occur as in response to clozapine treatment in chronic drug-resistant schizophrenic patients. Some of the latter m ay benefit from the addition of an SSRI to the ongoing clozapine regim en.