Feulgen-DNA content of sperm was quantified in fresh semen samples of
20 consecutive couples during preparation for in vitro fertilization t
o measure the condensation state of sperm chromatin. Results were expr
essed as a percentage of expected haploid DNA value (1c). No significa
nt differences were found between those who did not get pregnant, thos
e who went full term, and those who aborted. Because fertilization can
occur with a minority of normal sperm, it is concluded that the prese
nt findings do not provide useful clinical information about pregnancy
outcome and in vitro fertilization.