SYNTHESIS OF NEW DEAZATETRAHYDROPTERINS AS POTENTIAL NO SYNTHASE MODULATORS

Authors
NALLET JP MEGARD AL DREUX J
Citation
Jp. Nallet et al., SYNTHESIS OF NEW DEAZATETRAHYDROPTERINS AS POTENTIAL NO SYNTHASE MODULATORS, Bulletin de la Societe chimique de France, 133(5), 1996, pp. 491-500
Citations number
20
Categorie Soggetti
Chemistry Inorganic & Nuclear",Biology,Chemistry
Journal title
Bulletin de la Societe chimique de France → ACNP
ISSN journal
00378968
Volume
133
Issue
5
Year of publication
1996
Pages
491 - 500
Database
ISI
SICI code
0037-8968(1996)133:5<491:SONDAP>2.0.ZU;2-E
Abstract
As part of our research on NO synthase modulators, a series of deazate trahydropterins were synthesized and their effects were assessed. In t his paper, we describe the synthesis of new substituted (especially at the 4a position) mino-4-hydroxy-3,4,4a,5,6,7-hexahydropyrido[2,3-d] p yrimidines. These compounds showed no interesting pharmacological acti vity.