THE IMMUNOPATHOGENESIS OF MULTIPLE-SCLEROSIS AND GUILLAIN-BARRE-SYNDROME

Authors
GIOVANNONI G HARTUNG HP
Citation
G. Giovannoni et Hp. Hartung, THE IMMUNOPATHOGENESIS OF MULTIPLE-SCLEROSIS AND GUILLAIN-BARRE-SYNDROME, Current opinion in neurology, 9(3), 1996, pp. 165-177
Citations number
134
Categorie Soggetti
Neurosciences,"Clinical Neurology
Journal title
Current opinion in neurology → ACNP
ISSN journal
13507540
Volume
9
Issue
3
Year of publication
1996
Pages
165 - 177
Database
ISI
SICI code
1350-7540(1996)9:3<165:TIOMAG>2.0.ZU;2-4
Abstract
This review covers current hypotheses regarding antigen-specific disea se induction, immune responses within the central and peripheral nervo us systems, the nonspecific inflammatory cascade, and mechanisms respo nsible for demyelination, axonal loss, and disease progression in mult iple sclerosis and Guillain-Barre syndrome, We also discuss the new ev idence on the role of infection as an aetiological factor in multiple sclerosis and Guillain-Barre syndrome.