SYNTHESIS OF ENANTIOMERICALLY PURE (1R,2S)-2-AMINO-1,2-BIS(PENTAFLUOROPHENYL)ETHANOLS AND (1S,2R)-2-AMINO-1,2-BIS(PENTAFLUOROPHENYL)ETHANOLS

Authors
SAKAI T KUBO K KASHINO S UNEYAMA K
Citation
T. Sakai et al., SYNTHESIS OF ENANTIOMERICALLY PURE (1R,2S)-2-AMINO-1,2-BIS(PENTAFLUOROPHENYL)ETHANOLS AND (1S,2R)-2-AMINO-1,2-BIS(PENTAFLUOROPHENYL)ETHANOLS, Tetrahedron : asymmetry, 7(7), 1996, pp. 1883-1886
Citations number
19
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Inorganic & Nuclear","Chemistry Physical
Journal title
Tetrahedron : asymmetry → ACNP
ISSN journal
09574166
Volume
7
Issue
7
Year of publication
1996
Pages
1883 - 1886
Database
ISI
SICI code
0957-4166(1996)7:7<1883:SOEP(>2.0.ZU;2-Q
Abstract
Enantiomerically pure (1R,2S)- and (1S,2R)-2-amino-1,2-bis(pentanuorop henyl)-ethanols la and Ib have been prepared from ldimethylsiloxy)-2-( pentafluorophenyl)acetonitrile in three steps involving resolution of (+/-)-1 by salt formation with D-camphor-10-sulfonic acid. The absolut e configuration of la was established by X-ray crystallographic analys is after camphorsulfonylation. Copyright (C) 1996 Published by Elsevie r Science Ltd