MODELING OF AGITATION FLUIDIZED-BED GRANULATION BY RANDOM COALESCENCEMODEL

Citation
S. Watano et al., MODELING OF AGITATION FLUIDIZED-BED GRANULATION BY RANDOM COALESCENCEMODEL, Chemical and Pharmaceutical Bulletin, 44(7), 1996, pp. 1357-1360
Citations number
9
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
ISSN journal
00092363
Volume
44
Issue
7
Year of publication
1996
Pages
1357 - 1360
Database
ISI
SICI code
0009-2363(1996)44:7<1357:MOAFGB>2.0.ZU;2-G
Abstract
Modeling of agitation fluidized bed granulation was conducted using a proposed random coalescence model, in which adhesion of two colliding particles was judged by the coherent strength of a liquid bridge forme d between the particles and the separation force caused mainly by agit ator rotation, Properties of coherent strength and water absorbing cha racteristics of the starting materials, which were very important to d etermine granule growth, were also taken into consideration, Granule g rowth in various powder samples with different properties were simulat ed and the effects of moisture content and agitator rotational speed o n this growth were numerically investigated, The simulated results wer e in good agreement with the actual granulation data, and granule grow th in various powder samples and operating conditions could be simulat ed with high accuracy, The mechanism of agitation fluidized bed granul ation was also elucidated by the proposed model.