S. Watano et al., MODELING OF AGITATION FLUIDIZED-BED GRANULATION BY RANDOM COALESCENCEMODEL, Chemical and Pharmaceutical Bulletin, 44(7), 1996, pp. 1357-1360
Modeling of agitation fluidized bed granulation was conducted using a
proposed random coalescence model, in which adhesion of two colliding
particles was judged by the coherent strength of a liquid bridge forme
d between the particles and the separation force caused mainly by agit
ator rotation, Properties of coherent strength and water absorbing cha
racteristics of the starting materials, which were very important to d
etermine granule growth, were also taken into consideration, Granule g
rowth in various powder samples with different properties were simulat
ed and the effects of moisture content and agitator rotational speed o
n this growth were numerically investigated, The simulated results wer
e in good agreement with the actual granulation data, and granule grow
th in various powder samples and operating conditions could be simulat
ed with high accuracy, The mechanism of agitation fluidized bed granul
ation was also elucidated by the proposed model.