PREPARATION AND CHARACTERIZATION OF SEALED HEATED MIXTURE OF ETHENZAMIDE AND POROUS CALCIUM SILICATE

A sealed heated mixture of ethenzamide (EZ) and porous calcium silicat e (Florite(R) RE:FR) was prepared by heating the physical mixture in a sealed container, No diffraction peaks due to EZ crystals were observ ed in the powder X-ray diffraction pattern of the sealed heated mixtur e (FR:EZ = 9:1) nor was an endothermic peak observed on the differenti al scanning calorimetric measurement of the sealed heated mixture (FR: EZ = 9:1), indicating the amorphization of the EZ crystals caused by h eating in a sealed container, The sealed heated mixture with FR showed a greater dissolution rate than EZ crystals or the sealed heated mixt ure with nonporous calcium silicate (CS). The sealed heating method us ing porous FR thus provides a promising way of amorphizing EZ crystals without using any solvents and of improving the dissolution rate of E Z.