ANTITUMOR-PROMOTING ACTIVITIES OF VARIOUS SYNTHETIC O-(6'-O-ACYL-BETA-D-GALACTOPYRANOSYL)-SN-GLYCEROLS RELATED TO NATURAL PRODUCT FROM FRESH-WATER CYANOBACTERIUM ANABAENA-FLOS-AQUAE F FLOS-AQUAE

Authors
SHIRAHASHI H MORIMOTO T NAGATSU A MURAKAMI N TATTA K SAKAKIBARA J TOKUDA H NISHINO H
Citation
H. Shirahashi et al., ANTITUMOR-PROMOTING ACTIVITIES OF VARIOUS SYNTHETIC O-(6'-O-ACYL-BETA-D-GALACTOPYRANOSYL)-SN-GLYCEROLS RELATED TO NATURAL PRODUCT FROM FRESH-WATER CYANOBACTERIUM ANABAENA-FLOS-AQUAE F FLOS-AQUAE, Chemical and Pharmaceutical Bulletin, 44(7), 1996, pp. 1404-1406
Citations number
15
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Chemical and Pharmaceutical Bulletin → ACNP
ISSN journal
00092363
Volume
44
Issue
7
Year of publication
1996
Pages
1404 - 1406
Database
ISI
SICI code
0009-2363(1996)44:7<1404:AAOVSO>2.0.ZU;2-B
Abstract
O-(6'-O-acyl-beta-D-galactopyranosyl)-sn-glycerol, which was isolated from a nitrogen-fixing freshwater cyanobacterium, Anabaena flos-aquae f, flos-aquae, was synthesized by utilizing lipase-catalyzed acylation . The antitumor-promoting activities of these galactolipids were evalu ated using a short-term in vitro assay of Epstein-Barr virus activatio n in Raji cells induced by 12-O-tetradecanoyl-phorbol 13-acetate (TPA) . The glyceroglycolipids which have a palmitoleoyl residue at the 1-O- position exhibited more potent activities than the others in this assa y.