L. Harms et al., PROTON MAGNETIC-RESONANCE SPECTROSCOPY IN TRANSIENT CEREBROVASCULAR DISORDERS, Zurnal nevropatologii i psihiatrii im. S.S. Korsakova, 96(5), 1996, pp. 23-28
Proton magnetic resonance spectroscopy of the brain was performed in 8
patients with asymptomatic carotid stenosis as well as in 26 patients
with transient ischemic attacks (TIA) and 19 patients with reversible
ischemic neurologic deficiency (RIND). The study was carried out by m
eans of Philips apparatus, The results of investigation were compared
with data of spectroscopic examination of 9 older and 10 younger norma
ls, The mathematical analysis of ratio of N-acetylaspartate concentrat
ion (NAA) to phosphocholine (Pch), phosphocreatine (Pcr), and lactic a
cid was used to describe the metabolic changes, As a result lactic aci
d was not found in control volunteers' brains while It was detected ei
ther In the damaged (59%) or in the contralateral (47%) hemispheres of
the patients, The significant decrease of NAA/Pch and NAA/Pcr ratios
was observed in the pathological hemispheres of the patients, These re
sults testify to high sensitivity of proton magnetic resonance spectro
scopy for evaluation of metabolic disturbances in latent or reversible
cerebral ischemic.