LERIVON EFFECTIVITY AND MECHANISMS OF ACT ION IN ALCOHOLISM

Clinico-biological examination of 60 alcoholic patients was carried ou t, 30 patients were treated with lerivon (L) during 1 month, 15 contro l patients received amitriptylin for 1 month and 15 patients received relanium for 7 days, It was determined that L was quite effective in t reatment of depression In alcoholic patients. The main L effects were anxiolytic, antidepressive and hypnotic. The drug also decreased alcoh ol addiction, had vegetostabilising and sedative effects. The conclusi on was made on pathogenetic action of L in alcoholism: It influences u pon dopaminergic mediation in catecholamine system. Administration of L permitted to normalize neurochemical processes underlying alcohol ad diction and depression. L was well tolerated. Side effects complicatio ns, drug addiction were not registered.