INVESTIGATION OF THE LEVEL OF AUTOANTIBOD IES TO GLUTAMATE RECEPTORS IN BLOOD-SERUM OF PATIENTS IN ACUTE PERIOD OF ISCHEMIC STROKE

The level of autoantibodies (aAB) to main structural component of glut amate NMDA-receptors - phencyclidin-binding protein - was measured in blood serum of 70 patients during first 3, 6, 9, 12, 24 hours, and 3, 5 days after ischemic stroke development. 200 healthy individuals form ed the control group. The elevation of titers of aAB to glutamate rece ptors was observed in all patients with severe or moderate disease fro m the very first hours of stroke. It was especially pronounced by 9-12 hours after stroke, The highest increase of aAB titers was found in s evere cases, The tendency to normalization of aAB titers was observed by the end of the first twenty four hours, The degree of aAB elevation had the prognostic importance, The most favourable course of stroke w ith good restoration of damaged functions was predicted when stable no rmalization of the aAB level was observed by the third day of the dise ase development, Patients in stupor-coma condition did not show the ph enomenon of aAB level's elevation during the first days of stroke, tha t reflected, probably, the development of immuno-deficient state, The decrease of aAB level down to subnormal values was extremely unfavoura ble prognostic sign preceeding patient's death as a rule.