Ek. Choi et al., ALTERATIONS OF C-FOS GENE METHYLATION IN THE PROCESSES OF AGING AND TUMORIGENESIS IN HUMAN LIVER, Mutation research, 354(1), 1996, pp. 123-128
The state of DNA methylation in the c-fos gene was examined in human l
ivers of different ages, cirrhosis and hepatocellular carcinoma, The d
egree of methylation in the intron 1 to exon 4 region increased with a
ge, whereas all of the 10 cirrhosis samples revealed a decrease in met
hylation when compared to normal livers of similar ages. The 11 hepato
cellular carcinomas showed varied alterations suggesting that the alte
ration of the c-Sos gene methylation is related to aging as well as to
early-step of hepatocarcinogenesis.