ASSOCIATION OF APOLIPOPROTEIN-A-1, APOLIPOPROTEIN-B, AND APOLIPOPROTEIN-E WITH CARDIOVASCULAR-DISEASE RISK-FACTORS IN MEN - THE ST-PETERSBURG LIPID RESEARCH CLINICS STUDY

Previous studies have revealed a high incidence of coronary heart dise ase despite high levels of high-density lipoprotein-cholesterol, in a sample of men from St. Petersburg, Russia. This article describes the levers of apolipoproteins A-1, B, E, and their association with other coronary heart disease risk factors from a cross-sectional survey on a sample of 765 men aged 20-59, from the Voter registration rails of th e Petrogradski District of St. Petersburg. The results showed a signif icant increase of apolipoproteins with age. All apolipoproteins had a positive correlation with plasma cholesterol (for A-1, r = 0.18; for B , r = 0.65; for E, r = 0.57). Apolipoproteins B and E were positively correlated with low-density lipoprotein-cholesterol (r = 0.65 and 0.57 , respectively) and A-I was strongly correlated with high-density lipo protein-cholesterol (r = 0.49). In both univariable and multivariable analysis, apolipoprotein A-1 was associated with hypertension, and apo lipoprotein B and E were associated with body mass index. Thus, this s tudy shows that in men of St. Petersburg, Russia, there is a close rel ation of apolipoproteins to lipoproteins and a positive correlation be tween apolipoproteins and other coronary heart disease risk factors su ch as hypertension and body mass index.