DISTRIBUTION OF ALVEOLAR EDEMA IN VENTILATED AND UNVENTILATED CANINE LUNG LOBES

RATIONALE AND OBJECTIVES, Pulmonary edema frequently is treated with v entilation but its effects on the distribution of edema, including gra vity-dependent gradients as determined by computed tomography (CT) sca nning, are unclear, METHODS. TO study this, 30 to 50 mL 5% albumin in dextran were instilled in both caudal lobes of supine dogs, They were ventilated only on the left side for 1 minute (n = 4), 30 minutes (n = 6), or 60 minutes (n = 6), and the lobes excised, frozen, and imaged in a CT scanner, Regions of interest were outlined on regional CT slic es and tissue from corresponding regions taken for measurements of ext ravascular lung water (quantity of wet lung [Qwl]/dry quantity of lung [dQl]) and for histology to grade interstitial and alveolar edema. RE SULTS. After ventilation for 30 and 60 minutes, the CT density of the left caudal lobes was significantly lower than the right caudal lobes (P < 0.05), with no significant differences in their Qwl/dQl. Although gravity-dependent gradients of Qwl/dQl were demonstrated, they were u naffected by ventilation, Histology showed a trend for more interstiti al edema in left caudal lobes ventilated for 60 minutes compared with lobes ventilated for 1 minute (P = 0.054), CONCLUSIONS. Ventilation ap pears to act primarily by maintaining lung aeration and may play a min or role in alveolar fluid clearance.