SYNTHESIS OF [3.3.0]-BICYCLIC ISOXAZOLIDINYL NUCLEOSIDES

Authors
XIANG YJ SCHINAZI RF ZHAO K
Citation
Yj. Xiang et al., SYNTHESIS OF [3.3.0]-BICYCLIC ISOXAZOLIDINYL NUCLEOSIDES, Bioorganic & medicinal chemistry letters, 6(13), 1996, pp. 1475-1478
Citations number
21
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
6
Issue
13
Year of publication
1996
Pages
1475 - 1478
Database
ISI
SICI code
0960-894X(1996)6:13<1475:SO[IN>2.0.ZU;2-B
Abstract
The isoxazolidine derivative 6, prepared from an intermolecular 1,3-di polar cycloaddition of the (5S)-unsaturated lactone 5 and N-methylnitr one, was effectively used for the synthesis of [3.3.0] bicyclic isoxaz olidinyl cytidine 4a and thymidine 4b. Copyright (C) 1996 Elsevier Sci ence Ltd