UNUSUAL CYTOTOXICITIES OF 5-(ACYLETHYNYL)-1-(2-HYDROXYETHOXY)METHYLURACILS

Authors
KUNDU NG MAHANTY JS SPEARS CP
Citation
Ng. Kundu et al., UNUSUAL CYTOTOXICITIES OF 5-(ACYLETHYNYL)-1-(2-HYDROXYETHOXY)METHYLURACILS, Bioorganic & medicinal chemistry letters, 6(13), 1996, pp. 1497-1502
Citations number
23
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
6
Issue
13
Year of publication
1996
Pages
1497 - 1502
Database
ISI
SICI code
0960-894X(1996)6:13<1497:UCO5>2.0.ZU;2-Q
Abstract
5-(Acylethynyl)-1-(2-hydroxyethoxy)methyl uracils (2)-(6) were synthes ised in excellent yields from 1-(2-acetoxyethoxy)methyl-5-iodouracil ( 7) utilising palladium-copper catalysed reactions. Compounds (2)-(5) w ere shown to be highly active against CCRF-CEM (IC50 0.6-1.6 mu M) and L1210/0 cells (IC50 0.7-2.2 mu M) in culture, and thus exhibit greate r activity than their parent bases. Copyright (C) 1996 Elsevier Scienc e Ltd