SYNTHESIS AND BIOLOGICAL EVALUATION OF N-(1-AZIRIDINO)-6-FLUORO-QUINOLONE-3-CARBOXYLIC ACIDS

Authors
BATORI S TIMARI G KOCZKA I HERMECZ I
Citation
S. Batori et al., SYNTHESIS AND BIOLOGICAL EVALUATION OF N-(1-AZIRIDINO)-6-FLUORO-QUINOLONE-3-CARBOXYLIC ACIDS, Bioorganic & medicinal chemistry letters, 6(13), 1996, pp. 1507-1510
Citations number
17
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
6
Issue
13
Year of publication
1996
Pages
1507 - 1510
Database
ISI
SICI code
0960-894X(1996)6:13<1507:SABEON>2.0.ZU;2-R
Abstract
New racemic methylpiperazin-1-yl)-4(1H)-quinolone-3-carboxylic acids ( 9a-i) were synthesized and their antibacterial activities were tested against Gram-positive and Gramnegative micro-organisms. According to t he MIC, all compounds studied are less active than Ciprofloxacin; two of them (9a,b) have similar activity as Nalidixic acid (1). Copyright (C) 1996 Elsevier Science Ltd