ANTIOXIDANT AND CHOLESTEROL-LOWERING PROPERTIES OF I-T-BUTYL-4-[(DIMETHYLPHENYLSILYL)METHYLOXY]PHENOL AND DERIVATIVES - A NEW CLASS OF ANTI-ATHEROGENIC COMPOUNDS

Authors
PARKER RA BARNHART RL CHEN KS EDWARDS ML MATT JE RHINEHART BL ROBINSON KM VAAL MJ YATES MT
Citation
Ra. Parker et al., ANTIOXIDANT AND CHOLESTEROL-LOWERING PROPERTIES OF I-T-BUTYL-4-[(DIMETHYLPHENYLSILYL)METHYLOXY]PHENOL AND DERIVATIVES - A NEW CLASS OF ANTI-ATHEROGENIC COMPOUNDS, Bioorganic & medicinal chemistry letters, 6(13), 1996, pp. 1559-1562
Citations number
20
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
6
Issue
13
Year of publication
1996
Pages
1559 - 1562
Database
ISI
SICI code
0960-894X(1996)6:13<1559:AACPOI>2.0.ZU;2-9
Abstract
Di-t-butylphenol derivatives were synthesized and evaluated as antioxi dants and cholesterol lowering agents. When evaluated in cholesterol-f ed rabbits, the compounds were found to exhibit both properties. Of sp ecial interest was the finding that several of the compounds elevated HDL cholesterol levels. Copyright (C) 1996 Elsevier Science Ltd