ADIPOYL-6-AMINOPENICILLANIC ACID IS A SUBSTRATE FOR DEACETOXYCEPHALOSPORIN-C SYNTHASE (DAOCS)

Authors
SHIBATA N LLOYD MD BALDWIN JE SCHOFIELD CJ
Citation
N. Shibata et al., ADIPOYL-6-AMINOPENICILLANIC ACID IS A SUBSTRATE FOR DEACETOXYCEPHALOSPORIN-C SYNTHASE (DAOCS), Bioorganic & medicinal chemistry letters, 6(13), 1996, pp. 1579-1584
Citations number
22
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
6
Issue
13
Year of publication
1996
Pages
1579 - 1584
Database
ISI
SICI code
0960-894X(1996)6:13<1579:AAIASF>2.0.ZU;2-A
Abstract
Adipoyl-6-aminopenicillanic acid 5 was incubated with recombinant DAOC S and the resulting cephalosporin isolated. Adipoyl-6-aminopenicillani c acid 5 is approximately 735 times less efficient as a substrate for DAOCS in vitro (as judged by k(cat)/K-m) than penicillin N 1. Copyrigh t (C) 1996 Published by Elsevier Science Ltd