The amino acid sequence of the rat 60S ribosomal subunit protein L6 wa
s deduced from the sequence of nucleotides in a recombinant cDNA and c
onfirmed by determination of amino acid sequences in the protein. Ribo
somal protein L6 has 296 amino acids (the NH2-terminal methionine is r
emoved after translation of mRNA); the molecular weight is 33,417. Hyb
ridization of the cDNA to digests of nuclear DNA suggests that there a
re 7 to 10 copies of the L6 gene. The mRNA for the protein is about 1,
100 nucleotides in length. Rat L6 is related to ribosomal proteins fro
m other eukaryotes and to histone H1.