HIGH-PERFORMANCE THIN-LAYER CHROMATOGRAPHIC ANALYSIS OF HYDROLYZED TINIDAZOLE SOLUTIONS .2. HYDROLYSIS KINETICS OF TINIDAZOLE

Authors
SALO JP SALOMIES H
Citation
Jp. Salo et H. Salomies, HIGH-PERFORMANCE THIN-LAYER CHROMATOGRAPHIC ANALYSIS OF HYDROLYZED TINIDAZOLE SOLUTIONS .2. HYDROLYSIS KINETICS OF TINIDAZOLE, Journal of pharmaceutical and biomedical analysis, 14(8-10), 1996, pp. 1267-1270
Citations number
15
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Journal of pharmaceutical and biomedical analysis → ACNP
ISSN journal
07317085
Volume
14
Issue
8-10
Year of publication
1996
Pages
1267 - 1270
Database
ISI
SICI code
0731-7085(1996)14:8-10<1267:HTCAOH>2.0.ZU;2-0
Abstract
In a citrate-borate-phosphate buffer, 5 mM tinidazole solutions exhibi ted maximum stability around pH 4.0-5.0. The hydrolysis of tinidazole was mostly a first-order reaction. At pH 10.0 and 60-80 degrees C, tin idazole had an activation energy of 122 kJ mol(-1) for hydrolysis. It was postulated that tinidazole decomposes by different mechanisms unde r basic and neutral/acidic conditions.