ACTIVITY OF GLYCYLCYCLINES CL-329998 AND CL-331002 AGAINST MINOCYCLINE-RESISTANT AND OTHER STRAINS OF METHICILLIN-RESISTANT STAPHYLOCOCCUS-AUREUS

Authors
HAMILTONMILLER JMT SHAH S
Citation
Jmt. Hamiltonmiller et S. Shah, ACTIVITY OF GLYCYLCYCLINES CL-329998 AND CL-331002 AGAINST MINOCYCLINE-RESISTANT AND OTHER STRAINS OF METHICILLIN-RESISTANT STAPHYLOCOCCUS-AUREUS, Journal of antimicrobial chemotherapy, 37(6), 1996, pp. 1171-1175
Citations number
12
Categorie Soggetti
Microbiology,"Pharmacology & Pharmacy","Infectious Diseases
Journal title
Journal of antimicrobial chemotherapy → ACNP
ISSN journal
03057453
Volume
37
Issue
6
Year of publication
1996
Pages
1171 - 1175
Database
ISI
SICI code
0305-7453(1996)37:6<1171:AOGCAC>2.0.ZU;2-P
Abstract
Two glycylcyclines have been tested against 191 strains of methicillin -resistant Staphylococcus aureus, 72 of which were resistant to minocy cline, isolated from many parts of the world. MICs of CL 329998 ranged from 0.06 to 4 mg/L, with MIC(50) and MIC(50) 0.5 and 2 mg/L, respect ively. CL 331002 was slightly less potent, having an MIC range 0.12-16 mg/L and MIC(50) and MIC(90) values of 1 and 4 mg/L, respectively.