The existence of stable links and knots is demonstrated in three-dimen
sional, bistable, chemical media. The reaction-diffusion medium segreg
ates into regions of high and low concentration separated by sharp int
erfaces. The interfaces repel at short distances so that domains with
various topologies are possible, depending on the initial conditions a
nd system parameters. Front instabilities can give rise to knotted lab
yrinthine patterns. A lattice-gas model whose mean-field limit is the
FitzHugh-Nagumo equation is described and implemented to carry out the
simulations.