INTERLEUKIN-1-BETA AND TUMOR-NECROSIS-FACTOR-ALPHA COOPERATIVELY ENHANCE A NOVEL TROPHIC ACTIVITY OF ASTROCYTES FOR PONTINE CHOLINERGIC NEURONS IN-VITRO

Authors
KAMIGUCHI H YOSHIDA K INABA M SASAKI H OTANI M TOYA S
Citation
H. Kamiguchi et al., INTERLEUKIN-1-BETA AND TUMOR-NECROSIS-FACTOR-ALPHA COOPERATIVELY ENHANCE A NOVEL TROPHIC ACTIVITY OF ASTROCYTES FOR PONTINE CHOLINERGIC NEURONS IN-VITRO, Restorative neurology and neuroscience, 10(1), 1996, pp. 43-47
Citations number
18
Categorie Soggetti
Neurosciences
Journal title
Restorative neurology and neuroscience → ACNP
ISSN journal
09226028
Volume
10
Issue
1
Year of publication
1996
Pages
43 - 47
Database
ISI
SICI code
0922-6028(1996)10:1<43:IATCE>2.0.ZU;2-F
Abstract
Insulin and insulin-like growth factors (IGFs) are the only known trop hic factors for pontine cholinergic neurons. The present study reveale d that astrocyte-extract pretreated with IL-1 beta and TNF-alpha signi ficantly enhanced choline acetyltransferase (ChAT) activity of the pon tine neurons in the presence of a supramaximal dose of insulin; while various trophic factors including IGFs failed to increase the ChAT act ivity under the same culture conditions, suggesting that IL-1 beta and TNF-alpha co-operatively enhanced the expression of a novel trophic f actor for pontine cholinergic neurons in astrocytes.