The aims of the present study were as follows: 1) to evaluate the medi
cal outcomes of two treatment and educational asthma programs 2) to de
termine by cost-analysis both cost and economic outcome of the program
s 3) to perform a cost-benefit analysis (determining the net cost-bene
fit) and a cost-effectiveness analysis (determining the cost per unit
of effect and the incremental cost-effectiveness ratio) from the persp
ective of health program policy makers (HPP; indirect costs, i.e., los
s of productivity, excluded) and of society as a whole (SaW; all costs
included). Patients were randomly assigned to a complete (CP; n = 32)
or reduced (RP; n = 33) program: the RP group received a reduced educ
ation (self-reading of an educational booklet on asthma), while the CP
group attended an ''asthma school'' consisting of six lessons based o
n the same I booklet and including educational videotapes. Both progra
ms included peak-flow monitoring and treatment according to internatio
nal guidelines, and follow-up. The outcome variables (asthma attacks,
urgent medical a examinations, admission days, working days lost) did
not differ significantly between CP and RP. Morbidity savings were $18
94.70 (CP) and $1697.80 (RP) according to SaW, and $1349.50 and $1301.
80, respectively, according to HPP. The net cost-benefit was $1181.50
for CP and $1028.00 for RP, and the cost-benefit ratio per dollar spen
t was 1:2.6 for CP and 1:2.5 for RP, according to SaW. One day of admi
ssion prevented had a cost of $110.20 (CP) and $94.10 (RP). CP gave sl
ightly better results and was slightly more cost-effective than KP in
improving patients' welfare. It cannot be excluded that the retrospect
ive analysis used to determine baseline costs might have inflated diff
erences for both groups. Sensitivity analysis was slightly in favor of
RP when the outcome variables were tested at their upper and lower 95
% CI.