Bone marrow transplantation (BMT) has recently become the treatment of
choice for a number of malignancies. This procedure is highly technic
al, involving the use of radiation and chemotherapy to destroy the pat
ient's diseased bone marrow and with it functions of the entire immune
system. It is a process with toxic effect that are experienced by all
patients to varying degrees. A great deal of research related to the
physiological aspects of this procedure has already been done, but con
siderably fewer studies have examined the physiological aspects of the
BMT procedure from the patient's perspective. Knowledge about how BMT
patients understand this process and cope with its effects is importa
nt information for nurses taking care of these patients. The purpose o
f the study was to describe in depth the patterns of meaning employed
by patients in the hospital as they coped with the experience of their
BMT. Eleven patients were interviewed from one to four times a week t
hroughout their hospitalization. Hermeneutic analysis was used to iden
tify five major themes: physiological functioning, alertness, attitude
, social relationships, and spirituality. Implications from the findin
gs for nursing practice are discussed.